1330 Flexible fate determination ensures robust differentiation in the skin hair follicle
نویسندگان
چکیده
منابع مشابه
Hair follicle differentiation and regulation.
Ten years ago, Hardy (1992) wrote a timely review on the major features of hair follicle development and hair growth which she referred to as a secret life. Many of these secrets are now being revealed. The information discussed in this brief review comprises the structure of the hair and hair follicle, the continuing characterisation of the genes for keratin and keratin associated proteins, th...
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beta-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of beta-catenin in skin development, we introduced a conditional mutation of the gene in the epidermis and hair follicles using Cre/loxP technology. When beta-catenin is mutated during embryogenesis, formation of placodes that generate hair follicles is blocked. We ...
متن کاملIn vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin
Background: Hair follicle stem cells (HFSCs) located in the bulge area has shown to be highly proliferative and could differentiate into neurons, glia, smooth muscle cell, and melanocytes in vitro. Simvastatin is an HMG-CoA reductase inhibitor that exerts pleiotropic effects beyond simple low-density lipoprotein lowering and has a similar impact on the differentiation of bone marrow stromal cel...
متن کاملImmune reactions in skin and hair follicle gene therapy.
An immunological response to non-native proteins is a problem that must be overcome for successful gene therapy. A study by Ghazizadeh et al. in this issue of Molecular Therapy describes the immune response to retrovirus-mediated lacZ gene transfer to the skin [1]. The study shows that both CD4 and CD8 immune responses need to be eliminated to permit persistent expression of this transgene. The...
متن کاملCharacterization of Hair Follicle Development in Engineered Skin Substitutes
Generation of skin appendages in engineered skin substitutes has been limited by lack of trichogenic potency in cultured postnatal cells. To investigate the feasibility and the limitation of hair regeneration, engineered skin substitutes were prepared with chimeric populations of cultured human keratinocytes from neonatal foreskins and cultured murine dermal papilla cells from adult GFP transge...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.1347